Hydrochloric Acid → HCID 11165608, compound

Participants

Reaction Steps

Using an analogous procedure to that described paragraph (D) in the portion of Example 18 which is concerned with the preparation of starting materials tert-Butyl (3R)-3-[(3-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-4-oxo-3,4-dihydroquinazolin-6-yl)oxy]pyrrolidine-1-carboxylate was reacted with 4N HCl in dioxane. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 0.52 (m, 2H), 0.66 (m, 2H), 1.79 (m, 1H), 2.04 (m, 1H), 2.14 (s, 3H), 2.84 (m, 4H), 3.07 (m, 1H), 5.00 (m, 1 if), 7.48 (m, 3H), 7.71 (d, 1H), 7.82 (s, 1H), 7.89 (d, 1 if), 8.18 (s, 1H), 8.42 (s, 1 if); Mass Spectrum: M+H+ 405.

Provenance & Evidence