Potassium Iodide → HCID 66919140, compound

Participants

Reaction Conditions

Reaction Steps

3-[6-(2-Chloropropoxyoxy)-4-oxoquinazolin-3(4H)-yl]-N-cyclopropyl-4-methylbenzamide (0.23 g), thiomorpholine (0.37 g) and potassium iodide (0.2 g) were stirred in DMA (3 ml) and heated under microwave irradiation conditions (Personal Chemistry Emrys Optimizer with 300 W magnetron) for 30 mins at 120° C. The reaction mixture was filtered, washed with ethyl acetate and the filtrate concentrated. Purification by column chromatography on a silica column eluting with a 0% to 30% MeOH/EtOAc gradient gave the title compound (0.19 g) as a white solid; Mass Spectrum: M+H+ 479.

Provenance & Evidence