Boron tribromide → HCID 66918915, compound

Participants

Reaction Steps

Using an analogous procedure to that described in paragraph (A) in the portion of Example 24 which is concerned with the preparation of starting material, 2-amino-3-methoxybenzoic acid was reacted with 3-amino-N-cyclopropyl-4-methylbenzamide to give N-cyclopropyl-3-(8-methoxy-4-oxoquinazolin-3(4H)-yl)-4-methylbenzamide (AZ12304507); NMR Spectrum: (DMSOd6) 0.55 (m, 2H), 0.68 (m, 2H), 2.12 (s, 3H), 2.84 (m, 1H), 3.94 (s, 3H), 7.49 (m, 3H), 7.74 (d, 1H), 7.83 (s, 1H), 7.89 (d, 1H), 8.24 (s, 1H), 8.44 (s, 1H); Mass Spectrum: M+H+ 350. B) Using an analogous procedure to that described in paragraph (B) in the portion of Example 24 which is concerned with the preparation of starting material, N-cyclopropyl-3-(8-methoxy-4-oxoquinazolin-3(4H)-yl)-4-methylbenzamide was reacted with a 1M solution of boron tribromide in methylene chloride to give N-cyclopropyl-3-(8-hydroxy-4-oxoquinazolin-3(4H)-yl)-4-methylbenzamide; Mass Spectrum: M+H+ 336.

Provenance & Evidence