Methanesulfonic Acid → HCID 86610964, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 45, 1N methanesulfonic acid in ethyl acetate was reacted with N-cyclopropyl-3-[6-(4-isopropylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.70 (m, 2H), 1.30 (d, 6H), 2.14 (s, 3H), 2.35 (s, 3H), 2.85 (m, 1H), 3.10-3.28 (m, 4H), 3.55 (m, 3H), 4.07 (m, 2H), 7.53 (d, 1H), 7.57 (s, 1H), 7.71 (m, 2H), 7.82 (s, 1H), 7.91 (d, 1H), 8.18 (s, 1H), 8.44 (d, 1H), 9.40 (br s, 1H).

Provenance & Evidence