p-Toluenesulfonic acid → HCID 86610975, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 45, a 0.1N solution of 4-toluenesulfonic acid in ethyl acetate was reacted N-cyclopropyl-3-[6-{[(3S)-1-isopropylpyrrolidin-3-yl]oxy}-4-oxoquinazolin-3(4H)-yl]-4-methylbenzamide to gave the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.70 (m, 2H), 1.29 (m, 6H), 2.15 (s, 3H), 2.29 (m, 4H), 2.86 (m, 1H), 3.30 (m, 2H), 3.51 (m, 2H), 3.71 (m, 2H), 5.38 (m, 1H), 7.12 (d, 2H), 7.49 (d, 2H), 7.55 (m, 2H), 7.64 (d, 1H), 7.80 (d, 1H), 7.84 (m, 1H), 7.92 (m, 1H), 8.25 (s, 1H), 8.45 (d, 1H), 9.88 (d, 1H).

Provenance & Evidence