tert-Butyldimethylsilyl chloride → HCID 58775972, compound

Participants

Reaction Steps

Using a procedure analogous to Example 13A, 1-{(4-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (Example 1B) (4.91 g, 12.83 mmol) and TBSCl (1.93 g, 12.83 mmol) give the title compound (5.74 g, 11.57 mmol, 90%). 1H NMR (CDCl3), δ 0.21 (s, 6H), 0.60 (t, J=7.5 Hz, 6H), 1.01(s, 9H), 1.26 (s, 9H), 2.01 (q, J=7.5 Hz, 4H), 2.16 (s, 3H), 2.24 (s, 3H), 4.83 (s, 2H), 6.50 (d, J=8.4 Hz, 1H), 6.63 (d, J=8.4 Hz, 1H), 6.82 (dd, J=8.4, 2.3 Hz, 1H), 6.87-6.93 (m, 3H). LC/MS (m/z): calcd for C31H52NO3Si (M+NH4)+: 514.8; found: 514.5.

Provenance & Evidence