Water → 2-Chloro-4-methoxybenzaldehyde

Participants

Reaction Steps

To a suspension of 2-chloro-4-hydroxybenzaldehyde (0.50 g) and potassium carbonate (1.1 g) in N,N-dimethylformamide (5 mL) was added methyl iodide (0.40 mL) at room temperature, and the mixture was stirred at room temperature for 5 hours. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The extract was washed with water and brine successively, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 2-chloro-4-methoxybenzaldehyde (0.54 g). The title compound was prepared in a similar manner to that described in Reference Example 45 using this material instead of 4-isobutyl-benzaldehyde.

Provenance & Evidence