Water → HCID 14570119, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxabororan-2-yl)benzoate (1.0 g), 1-benzyloxy-3-iodobenzene (1.18 g), tetrakis(triphenylphosphine)palladium(0) (0.22 g) and potassium carbonate (1.58 g) in toluene (10 mL) was stirred at 100° C. under an argon atmosphere overnight. The reaction mixture was poured into water, and the resulting mixture was extracted with ethylacetate. The extract was washed with water and brine successively, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate=9/1-4/1) to give methyl 4-[3-(benzyloxy)phenyl]benzoate (1.2 g).

Provenance & Evidence