Hydrochloric Acid → HCID 86628793, compound

Participants

Reaction Steps

To a solution of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-7-chloro-1-[4-(2-hydroxyethoxy)benzyl]-1H-indole (0.23 g) and triethylamine (0.076 mL) in dichloromethane (4 mL) was added methanesulfonyl chloride (0.034 mL), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into 1 mol/L hydrochloric acid, and the resulting mixture was extracted with ethylacetate. The extract was washed with water and brine successively, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-7-chloro-1-{4-[2-(methanesulfonyloxy)ethoxy]-benzyl}-1H-indole (0.25 g).

Provenance & Evidence