HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 6,7-Dichloroquinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethyl oxoacetate | HCID 70211 | — |
| Reactant | 4,5-Dichloro-1,2-phenylenediamine | HCID 79297 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6,7-Dichloroquinoxalin-2(1H)-one | HCID 14423636 | — |
Reaction Steps
4,5-Dichlorophenylenediamine (26.0 g, 147 mmol) and 50% ethyl glyoxylate in toluene (32 mL, 161 mmol) in ethanol (250 mL) was refluxed for 18 h. The reaction was cooled and the crystallized brown product was collected by filtration, then washed with ethanol (50 mL). The obtained product (25.5 g, 81%) was 96% pure via LC/MS. MS (ES) m/e 215[M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07749998B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-ca0ac27917944e98865cba674a2c9963 |
| Source note | uspto-grants-2010_07 |