42174-34-5 → HCID 15091485, compound

HRID 2354323Notes

Reaction equation

HRID 2354323 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:19])/[CH:11]=[CH:12]/C2C=CC=CC=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[Al+3].[Cl-].[Cl-].[Cl-]>>[Cl:8][C:7]1[CH:6]=[C:5]2[C:4](=[CH:3][C:2]=1[Cl:1])[NH:9][C:10](=[O:19])[CH:11]=[CH:12]2

Participants

3

Reactant 2

HCID 540351042174-34-5HCID 6451240Aluminum(III) Chloride

Product 1

HCID 15091485HCID 15091485, compound

Procedure

A mixture of (2E)-N-(3,4-dichlorophenyl)-3-phenyl-2-propenamide (4.0 g, 13.7 mmol) and AlCl3 (9.1 g, 68.5 mmol) was heated slowly until the mixture became liquefied and then subsequently congealed to form a solid cake. Ice was slowly added to break up the hardened material. The mixture was vigorously stirred for 2 h. The precipitate was collected and washed with 2 N HCl solution, water, and ether to obtain a white mixture of product A and B above (2.8 g, 96%), MS (ES) m/e 215 [M+H]+.

Workup

  1. temperaturewas heated slowly until the mixture
  2. customto form a solid cake
  3. additionIce was slowly added
  4. customThe precipitate was collected
  5. washwashed with 2 N HCl solution, water, and ether
  6. customto obtain

Sources & evidence

ORD record
ord-09561e83df114faca93a547683f6d632
Source dataset
uspto-grants-2010_07
Patent number
US07749998B2

Reaction notes

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