(4-Methanesulfonamidophenyl)boronic acid → 2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4'-[(methylsulfonyl)amino]-4-biphenylyl]-2-(4-morpholinyl)ethyl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	(4-Methanesulfonamidophenyl)boronic acid	HCID 2773537	—
Reactant	N-[1-(4-bromophenyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide	HCID 57457161	—
Product	2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methyl-N-[1-{4'-[(methylsulfonyl)amino]-4-biphenylyl]-2-(4-morpholinyl)ethyl]acetamide	HCID 46847714	—

Reaction Steps

The title compound was prepared according to example 33, using the intermediate from step c) and {4-[(methylsulfonyl)amino]-phenyl}boronic acid, MS (ES) m/e 647 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07749998B2
Source dataset	uspto-grants-2010_07
ORD ID	ord-8a8d5244837447feb322c4934e77fe44
Source note	uspto-grants-2010_07