Trifluoroacetic acid → N-[1-(4'-amino-4-biphenylyl)-2-(4-morpholinyl)ethyl]-2-(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)-N-methylacetamide

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl {4′-[1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylyl}carbamate (0.64 g, 0.96 mmol) in dichloromethane (4 mL) was added trifluoroacetic acid (4 mL). The resultant mixture was stirred at room temperature for 1 h. The mixture was concentrated under reduced pressure to give 0.55 g (100%) of the title compound as tan solid MS (ES) m/e 569.4 [M+H]+.

Provenance & Evidence