HCID 178434605, compound → HCID 178434604, compound

HRID 23544Notes

Reaction equation

HRID 23544 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)=[C:5]([CH:13]=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[NH:4][N:3]=1.CC1C(C2C=CN=CC=2)=C(CCC2C=CC=CC=2)NN=1>CO.[Pd]>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)=[C:5]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[NH:4][N:3]=1

Participants

4

Reactant 1

HCID 178434605HCID 178434605, compound

Product 1

HCID 178434604HCID 178434604, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-[3-Methyl-5-(2-phenylethyl)-1H-pyrazol-4-yl]pyridine 4-(3-Methyl-5-(2-phenylethenyl)-1H-pyrazol-4-yl)pyridine (Example 1) (0.177 g, 0.67 mmol) was hydrogenated (5-30 psi) in MeOH in the presence of a catalytic amount of 4% Pd/C at RT for 12 hours. The resulting mixture was filtered and the resulting solution was concentrated to give 4-(3-methyl-5-phenylethyl-1H-pyrazol-4-yl)pyridine quantitatively: MS (M+H+) 264 (100%).

Workup

  1. customat RT
  2. customfor 12 hours
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe resulting solution was concentrated

Sources & evidence

ORD record
ord-6e383f1abb664412814af60cc2b2257a
Source dataset
uspto-grants-2005_02
Patent number
US06852740B2

Reaction notes

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