HRID2354425

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734657

4-Acetamidophenylboronic acid

C8H10BNO3

HCID57418651

未命名化合物

HCID57501277

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(-c2ccc([C@H](CN3CCCC3)N(C)C(=O)CN(CC#N)c3ccc(Cl)c(Cl)c3)cc2)cc1

HCID59809643

未命名化合物

PROCEDURE

实验过程

Proceeding in a similar manner as in example 85, but replacing 1-(4-bromophenyl)-N-methyl-2-(1-pyrrolidinyl)ethanamine with (1R)-1-(4-bromophenyl)-N-methyl-2-(1-pyrrolidinyl)ethanamine and replacing (6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetic acid with N-(cyanomethyl)-N-(3,4-dichlorophenyl)glycine in step a) and replacing 3,4-dimethoxyphenylboronic acid with [4-(acetylamino) phenyl]boronic acid in step b), the title compound was prepared. MS (ES) m/e 578 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4b34d3361e32457489db7fa194f3e886
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07749998B2
来源说明: uspto-grants-2010_07

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:15][CH3:16])[CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[C:17]([CH2:19][N:20]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=1)[CH2:21][C:22]([OH:24])=O)#[N:18].[C:33]([NH:36][C:37]1[CH:42]=[CH:41][C:40](B(O)O)=[CH:39][CH:38]=1)(=[O:35])[CH3:34]>>[C:33]([NH:36][C:37]1[CH:42]=[CH:41][C:40]([C:2]2[CH:7]=[CH:6][C:5]([C@@H:8]([N:15]([CH3:16])[C:22](=[O:24])[CH2:21][N:20]([CH2:19][C:17]#[N:18])[C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=3)[CH2:9][N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)=[CH:4][CH:3]=2)=[CH:39][CH:38]=1)(=[O:35])[CH3:34]