4-Aminocarbonylphenylboronic acid → HCID 46846504, compound

HRID 2354452Notes

Reaction equation

HRID 2354452 reaction equation
[Cl:1][C:2]1[C:3]([Cl:40])=[CH:4][C:5]2[O:10][CH2:9][C:8](=[O:11])[N:7]([CH2:12][C:13]([N:15]([CH3:38])[C@H:16]([C:23]3[CH:28]=[CH:27][C:26](C4C=CC=C(C(N)=O)C=4)=[CH:25][CH:24]=3)[CH2:17][N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[O:14])[C:6]=2[CH:39]=1.[NH2:41][C:42]([C:44]1[CH:49]=[CH:48][C:47](B(O)O)=[CH:46][CH:45]=1)=[O:43]>>[Cl:1][C:2]1[C:3]([Cl:40])=[CH:4][C:5]2[O:10][CH2:9][C:8](=[O:11])[N:7]([CH2:12][C:13]([N:15]([CH3:38])[C@H:16]([C:23]3[CH:24]=[CH:25][C:26]([C:47]4[CH:48]=[CH:49][C:44]([C:42]([NH2:41])=[O:43])=[CH:45][CH:46]=4)=[CH:27][CH:28]=3)[CH2:17][N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:14])[C:6]=2[CH:39]=1

Participants

3

Reactant 2

HCID 27378114-Aminocarbonylphenylboronic acidHCID 468465031003877-55-1

Product 1

HCID 46846504HCID 46846504, compound

Procedure

4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-4-biphenylcarboxamide was prepared in a similar manner as in the preparation of 4′-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)acetyl](methyl)amino]-2-(1-pyrrolidinyl)ethyl]-3-biphenylcarboxamide except replacing [3-(aminocarbonyl)phenyl]boronic acid with [4-(aminocarbonyl)phenyl]boronic acid. As is appreciated by those skilled in the art, this analogous example may involve variations in synthetic procedure.

Sources & evidence

ORD record
ord-2dd26803f91a442a956dd6b17ff00b64
Source dataset
uspto-grants-2010_07
Patent number
US07749998B2

Reaction notes

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