Galactaric acid → HCID 131728242, compound

Participants

Reaction Steps

A solution of (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane (0.23 g, 0.70 mmol) in ethanol (3 mL) and water (2 mL) was heated at 60° C. as mucic acid (0.069 g, 0.33 mmol) was added. The mixture was heated for 30 min, then filtered through glass wool and concentrated to approximately 1 mL. The solution was added dropwise to acetone (12 mL). The precipitate was collected, washed with diethyl ether (2 mL) and dried at 45° C. for 4 h to afford 0.200 g (65%) of fine white crystals; m.p. 172° C. (d).

Provenance & Evidence