HRID2354514

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13981373

Fluoro(iodo)methane

CH2FI

结构：C[C@H](NC(=O)C(C)(C)Oc1cc(C(F)(F)F)ccn1)[C@@H](Cc1ccc(O)cc1)c1cccc(C#N)c1

HCID68657347

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)C(C)(C)Oc1cc(C(F)(F)F)ccn1)[C@@H](Cc1ccc(OCF)cc1)c1cccc(C#N)c1

HCID11353054

未命名化合物

PROCEDURE

实验过程

N-(1S,2S)-[2-(3-Cyanophenyl)-3-(4-fluoromethoxyphenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide was prepared from N(1S,2S)-[2-(3-cyanophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide (Example 12, Step B) and fluoromethyliodide following the procedure described in Example 4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e475cc81639e45718a083fdf1bba9298
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07754188B2
来源说明: uspto-grants-2010_07

反应 SMILES

[C:1]([C:3]1[CH:4]=[C:5]([C@H:9]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)[C@@H:10]([NH:12][C:13](=[O:28])[C:14]([O:17][C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][N:19]=2)([CH3:16])[CH3:15])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[F:37][CH2:38]I>>[C:1]([C:3]1[CH:4]=[C:5]([C@H:9]([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([O:36][CH2:38][F:37])=[CH:32][CH:31]=2)[C@@H:10]([NH:12][C:13](=[O:28])[C:14]([O:17][C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:25])[F:26])[CH:21]=[CH:20][N:19]=2)([CH3:16])[CH3:15])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]