Hydrochloric Acid → 3-Formyl-1,2,7,8,9,10,11,13-octahydro-13-oxo-4-(propylthio)-[l]benzothieno[2',3': 4,5] pyrimido[1,2-a]azepine-9-carboxylic acid methyl ester

Participants

Reaction Steps

Compound 22 80.37 mmol) was dissolved into MeOH (10 ml), and KOH (0.98 mmol) in MeOH (5 ml) was added. The reaction mixture was stirred for 2 hours in room temperature. The reaction mixture was poured into water, acidified with HCl and extracted with CH2Cl2. Organic layer was washed with brine and dried with Na2SO4. After filtration the solvent was evaporated. Purification by flash chromatography using CH2Cl2-EtOAc 9:1 as an eluent afforded compound 23 as a major product and compound 24 as a minor product.

Provenance & Evidence