Methyl 4-amino-3-[(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carbonyl)amino]benzoate → HCID 178497337, compound

HRID 2354574Notes

Reaction equation

HRID 2354574 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[NH:12][C:13]([C:15]1[C:16](=[O:27])[NH:17][N:18]=[C:19]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[CH:20]=1)=O>C(O)(=O)C>[O:27]=[C:16]1[C:15]([C:13]2[NH:1][C:2]3[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=3[N:12]=2)=[CH:20][C:19]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)=[N:18][NH:17]1

Participants

3

Reactant 1

HCID 68452535Methyl 4-amino-3-[(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carbonyl)amino]benzoate

Product 1

HCID 178497337HCID 178497337, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 1.3 g of methyl 4-amino-3-[(3-oxo-6-pyridin-4-yl-2,3-dihydro-pyridazine-4-carbonyl)amino]benzoate and 20 ml of glacial acetic acid is heated with stirring at 100° C. for 10 hours. The precipitate which has formed is filtered off with suction, washed with water and dried in vacuo at 50° C.

Workup

  1. temperatureis heated
  2. customThe precipitate which has formed
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-8cc2fe86d5d24c03bbd26180da30733d
Source dataset
uspto-grants-2010_07
Patent number
US07754713B2

Reaction notes

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