6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide → HCID 178463409, compound

HRID 2354582Notes

Reaction equation

HRID 2354582 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[C:13](=[O:27])[NH:14][N:15]=[C:16]([C:18]2[CH:23]=[CH:22][N:21]=[C:20]([NH:24][CH2:25][CH3:26])[N:19]=2)[CH:17]=1)=O>C(O)(=O)C>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]2[NH:9][C:10]([C:12]3[C:13](=[O:27])[NH:14][N:15]=[C:16]([C:18]4[CH:23]=[CH:22][N:21]=[C:20]([NH:24][CH2:25][CH3:26])[N:19]=4)[CH:17]=3)=[N:1][C:2]=2[CH:7]=1

Participants

3

Reactant 1

HCID 866116046-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

Product 1

HCID 178463409HCID 178463409, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-4-chlorophenyl)amide (50 mg) are stirred in 1 ml of glacial acetic acid at 100° C. for 3 hours. After cooling, the precipitate is filtered off with suction, stirred with aqueous sodium bicarbonate solution and again filtered off with suction, washed with water and dried in vacuo.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off with suction
  3. filtrationagain filtered off with suction
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-79ca58e0d0dc4f99a1a9d282828b9bab
Source dataset
uspto-grants-2010_07
Patent number
US07754713B2

Reaction notes

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