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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2354683Generated: October 31, 2026

5-Fluoro-2-(trifluoromethyl)benzoyl chloride → 6-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOBUTYLETHYL)AMIDE

https://huagongshe.com/reaction/2354683

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 2737560—
ReactantN-(2-Cyclobutylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849365—
Product6-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOBUTYLETHYL)AMIDEHCID 11294562—

Reaction Steps

Following the procedure of Example 3, making variations only as required to use 5-fluoro-2-(trifluoromethyl)benzoyl chloride in place of isoxazole-5-carbonyl chloride to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclobutylethyl)amide, the title compound was obtained as a white powder (71% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07754711B2
Source datasetuspto-grants-2010_07
ORD IDord-fd0dd9f4d0884446b0166878187c3a77
Source noteuspto-grants-2010_07