HCID 66849176, compound → HCID 86597219, compound

HRID 2354716Notes

Reaction equation

HRID 2354716 reaction equation
[CH3:1][N:2]1[N:6]=[C:5]([C:7]([OH:9])=O)[C:4]([C:10]([F:13])([F:12])[F:11])=[N:3]1.[CH3:14][CH:15]([CH3:33])[CH2:16][CH2:17][NH:18][C:19]([C:21]1[N:22]=[N:23][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:25][CH:26]=1)=[O:20]>>[CH3:14][CH:15]([CH3:33])[CH2:16][CH2:17][NH:18][C:19]([C:21]1[N:22]=[N:23][C:24]([N:27]2[CH2:32][CH2:31][N:30]([C:7]([C:5]3[C:4]([C:10]([F:13])([F:12])[F:11])=[N:3][N:2]([CH3:1])[N:6]=3)=[O:9])[CH2:29][CH2:28]2)=[CH:25][CH:26]=1)=[O:20]

Participants

3

Reactant 2

HCID 66849176HCID 66849176, compoundHCID 668493226-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amide

Product 1

HCID 86597219HCID 86597219, compound

Procedure

Following the procedure of Example 9, making variations only as required to use 2-methyl-5-trifluoromethyl-2H-[1,2,3]triazole-4-carboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white powder (15% yield). 1H NMR (300 MHz, DMSO-d6) δ 8.05, 7.83, 7.00, 4.28, 3.97-3.67, 3.51-3.45, 1.75-1.68, 1.49, 0.92. MS (ES+) m/z 455.2 (M+1).

Sources & evidence

ORD record
ord-b5c8699727fe42a1b989240c4659c392
Source dataset
uspto-grants-2010_07
Patent number
US07754711B2

Reaction notes

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