6-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amide → HCID 178446489, compound

HRID 2354717Notes

Reaction equation

HRID 2354717 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[N:7]=[CH:6][NH:5][C:4]=1[C:8]([OH:10])=O.[CH3:13][CH:14]([CH3:32])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[N:21]=[N:22][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:24][CH:25]=1)=[O:19]>>[CH3:13][CH:14]([CH3:32])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[N:21]=[N:22][C:23]([N:26]2[CH2:31][CH2:30][N:29]([C:8]([C:4]3[NH:5][CH:6]=[N:7][C:3]=3[C:2]([F:1])([F:12])[F:11])=[O:10])[CH2:28][CH2:27]2)=[CH:24][CH:25]=1)=[O:19]

Participants

3

Reactant 2

HCID 668493226-Piperazin-1-yl-pyridazin-3-carboxylic acid (3-methylbutyl)amideHCID 178524915HCID 178524915, compound

Product 1

HCID 178446489HCID 178446489, compound

Procedure

Following the procedure of Example 9, making variations only as required to use 5-trifluoromethyl-3H-imidazole-4-carboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-ylpyridazine-3-carboxylic acid (3-methylbutyl)amide, the title compound was obtained as a white powder (48% yield). 1H NMR (300 MHz, DMSO-d6) δ 8.03, 7.86, 7.70, 6.99, 3.80, 3.46, 1.75-1.62, 1.48, 0.92. MS (ES+) m/z 440.2 (M+1).

Sources & evidence

ORD record
ord-f8f2b841bf8a4ce59bc13777110211f1
Source dataset
uspto-grants-2010_07
Patent number
US07754711B2

Reaction notes

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