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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2354731생성일: 2026년 10월 25일

2-(Trifluoromethyl)cyclopropane-1-carboxylic acid → 6-[4-(2-TRIFLUOROMETHYLCYCLOPROPANECARBONYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDE

https://huagongshe.com/reaction/2354731

반응식

참여 물질

역할이름HCID투입량
반응물2-(Trifluoromethyl)cyclopropane-1-carboxylic acidHCID 13379935—
반응물N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamideHCID 66849327—
생성물6-[4-(2-TRIFLUOROMETHYLCYCLOPROPANECARBONYL)PIPERAZIN-1-YL]-PYRIDAZINE-3-CARBOXYLIC Acid (2-CYCLOPROPYLETHYL)AMIDEHCID 11258405—

반응 단계

Following the procedure of Example 9, making variations only as required to use 2-trifluoromethylcyclopropanecarboxylic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (30.9% yield). 1H NMR (300 MHz, CDCl3) δ 8.03, 7.98, 7.00, 3.97-3.57, 2.20, 1.65, 1.50, 1.26, 0.75, 0.46, 0.09. MS (ES+) m/z 412 (M+1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07754711B2
출처 데이터셋uspto-grants-2010_07
ORD IDord-739e97200da64946b292fca00e80f75b
출처 메모uspto-grants-2010_07