1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 66849413, compound

HRID 2354770Notes

Reaction equation

HRID 2354770 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:15]=[N:16][C:17](Cl)=[CH:18][CH:19]=1)=[O:13].[N:21]1([C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:35]([F:38])([F:37])[F:36])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:15]=[N:16][C:17]([N:24]2[CH2:25][CH2:26][N:21]([C:27](=[O:28])[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]([F:38])([F:36])[F:37])[CH2:22][CH2:23]2)=[CH:18][CH:19]=1)=[O:13]

Participants

3

Reactant 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 86025945HCID 86025945, compound

Product 1

HCID 66849413HCID 66849413, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid [2-(2,4-difluorophenyl)ethyl]amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (33% yield). m.p. 179-181° C. 1H NMR (400 MHz, CDCl3) δ 8.04, 7.91, 7.75, 7.61, 7.37, 7.30-6.89, 4.09-3.66, 3.38-3.32, 2.88. MS (ES+) m/z 520 (M+1).

Sources & evidence

ORD record
ord-241fb058d41246e4b453237166e1b7e8
Source dataset
uspto-grants-2010_07
Patent number
US07754711B2

Reaction notes

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