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HRID 2354778作成日：2026年10月25日

1-[2-(Trifluoromethyl)benzoyl]piperazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid [2-(2-FLUOROPHENYL)ETHYL]AMIDE

https://huagongshe.com/reaction/2354778

反応式

関与物質

役割名称HCID仕込み量
反応物1-[2-(Trifluoromethyl)benzoyl]piperazineHCID 16733784—
反応物6-Chloropyridazine-3-carboxylic acid [2-(2-fluorophenyl)ethyl]amideHCID 60860171—
生成物6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid [2-(2-FLUOROPHENYL)ETHYL]AMIDEHCID 66849618—

反応手順

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid [2-(2-fluorophenyl)ethyl]amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (70.7% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.95, 7.75-7.72, 7.63, 7.55, 7.36, 7.22-7.15, 7.05-6.97, 4.07-4.02, 3.89-3.83, 3.79-3.67, 3.35-3.32, 2.96.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07754711B2
出典データセットuspto-grants-2010_07
ORD IDord-f5e2b65eabcd40e0992db047493c9575
出典メモuspto-grants-2010_07