1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 67011161, compound

HRID 2354782Notes

Reaction equation

HRID 2354782 reaction equation
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]=[N:14][C:15](Cl)=[CH:16][CH:17]=2)=[O:11])=[CH:3][CH:2]=1.[N:25]1([C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[C:39]([F:42])([F:41])[F:40])=[O:32])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]=[N:14][C:15]([N:28]3[CH2:29][CH2:30][N:25]([C:31](=[O:32])[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=4[C:39]([F:42])([F:40])[F:41])[CH2:26][CH2:27]3)=[CH:16][CH:17]=2)=[O:11])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 86025959HCID 86025959, compound

Product 1

HCID 67011161HCID 67011161, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid (2-biphenyl-4-yl-ethyl)amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white powder (63.2% yield). 1H NMR (500 MHz, CDCl3) δ 8.07, 7.98, 7.76, 7.64, 7.60-7.52, 7.44, 7.38-7.30, 7.00, 4.06, 3.88, 3.82-3.68, 3.36, 2.98.

Sources & evidence

ORD record
ord-eff58d496685493e9b326407ba58ffe2
Source dataset
uspto-grants-2010_07
Patent number
US07754711B2

Reaction notes

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