1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 67012215, compound

HRID 2354804Notes

Reaction equation

HRID 2354804 reaction equation
[CH2:1]([NH:7][C:8]([C:10]1[N:11]=[N:12][C:13](Cl)=[CH:14][CH:15]=1)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[N:17]1([C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]([F:34])([F:33])[F:32])=[O:24])[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[CH2:1]([NH:7][C:8]([C:10]1[N:11]=[N:12][C:13]([N:20]2[CH2:21][CH2:22][N:17]([C:23](=[O:24])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([F:34])([F:32])[F:33])[CH2:18][CH2:19]2)=[CH:14][CH:15]=1)=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 61041519HCID 61041519, compound

Product 1

HCID 67012215HCID 67012215, compound

Procedure

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid hexylamide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethyl-phenyl)methanone, the title compound was obtained as a white powder (35% yield). 1H NMR (300 MHz, CDCl3) δ 8.02, 7.85, 7.72, 7.56, 7.34, 6.97, 4.00, 3.90-3.64, 3.48-3.28, 1.58, 1.29, 0.85. 13C NMR (75 MHz, CDCl3) 6167.6, 162.9, 160.0, 145.5, 134.3, 132.8, 129.5, 127.6, 127.2, 126.9, 125.4, 46.4, 44.6, 44.4, 41.3, 39.4, 31.5, 29.5, 26.6, 22.6, 14.0. MS (ES+) m/z (%) 464 (M+1).

Sources & evidence

ORD record
ord-51c8d08ce2614307bd9015900e7fe2c3
Source dataset
uspto-grants-2010_07
Patent number
US07754711B2

Reaction notes

Loading…