Butylamine → 2-Butylaminoadenine

HRID 2354828Notes

Reaction equation

HRID 2354828 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 949042-Chloroadenine

Product 1

HCID 34879632-ButylaminoadenineYield 30%

Procedure

2-Chloroadenine (6.0 g, 35.4 mmol) and n-butylamine (30 ml) were reacted in an autoclave (200 ml) at 130° C. for 150 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into water to precipitate the solid. The precipitated solid was successively washed with methylene chloride and methanol to give the captioned compound (2.08 g, yield 30%) as a yellowish orange powdered solid.

Workup

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. additionthe residue was poured into water
  3. customto precipitate the solid
  4. washThe precipitated solid was successively washed with methylene chloride and methanol

Sources & evidence

ORD record
ord-debc8edaefc5438b977e7327af820497
Source dataset
uspto-grants-2010_07
Patent number
US07754728B2

Reaction notes

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