Tert-butyl 3,4-dihydroxypyrrolidine-1-carboxylate → 1,1-Dimethylethyl N,N-bis(2-oxoethyl)carbamate

Participants

Reaction Steps

Sodium periodate (20.31 g, 94.96 mmol) in H2O (118 mL) was added to a cooled solution of 3,4-dihydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (19.3 g, 94.6 mmol) in THF (158 mL) over a 30 minute period. The resulting white suspension was allowed to stir at room temperature for 3 h. The suspension was filtered and the filtrate concentrated under vacuum to remove the THF. The resulting aqueous solution was used directly in the next reaction.

Provenance & Evidence