Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 10456102 | HCID 10456102 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10001463 | HCID 10001463 | — |
Reaction Steps
Acetyl chloride (60 μl) was added to a solution of the product from Example 46 step a) and triethylamine (0.13 ml) in dichloromethane (3 ml) at 0° C. and stirred at 20° C. for 1 hour. Water was added and the mixture was extracted with dichloromethane. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, ethyl acetate as eluent) to give the sub-title compound (290 mg). M.p. 281-4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07754735B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-432e1094c45f412a91a9b911a7628125 |
|---|
| Source note | uspto-grants-2010_07 |
|---|
