HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → n-[2-(3-Chloro-5-trifluoromethyl-pyridin-2-yl) ethyl]-2-trifluoromethyl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | PyBroP | HCID 2733179 | — |
| Reactant | 2-(Trifluoromethyl)pyridine-3-carboxylic acid | HCID 2777547 | — |
| Reactant | 3-Chloro-5-(trifluoromethyl)-2-pyridineethanamine | HCID 11961968 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | n-[2-(3-Chloro-5-trifluoromethyl-pyridin-2-yl) ethyl]-2-trifluoromethyl-nicotinamide | HCID 11741540 | — |
Reaction Steps
A solution of 204 mg (1 mmol) of 2-trifluormethyl nicotinic acid, 200 mg (0.9 mmol) of 2-(3-chloro-5-trifluormethyl-pyridin-2-yl)-ethylamine and 620 mg (1.3 mmol) of bromotripyrrolidinophosphonium hexafluorophosphate and 230 mg (1.8 mmol) N,N-Diisopropylethylamine in 8 ml methylene chloride is stirred for 20 h at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754741B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-b9119123c97c4878931e45b996798e7a |
| Source note | uspto-grants-2010_07 |