Dichloromethane methanol → HCID 67544122, compound

HRID 2354952Notes

Reaction equation

HRID 2354952 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[C@@H:10]([O:28][CH2:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)[CH2:9]1)=O)(C)(C)C.C(Cl)[Cl:41].CO>>[ClH:41].[CH3:27][O:26][C:23]1[CH:24]=[CH:25][C:20]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([C@H:11]3[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]3[O:28][CH2:29][C:30]3[CH:39]=[CH:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=3)[CH:15]=2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 21226129Dichloromethane methanolHCID 67544308HCID 67544308, compound

Product 1

HCID 67544122HCID 67544122, compound

Procedure

The title compound is prepared analogously as described for the title D compound in Example 1 from (3R*,4R*)-4-(4′-methoxy-biphenyl-3-yl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid t-butyl ester: MS 424.5 [M+H]+; Rf 0.24 (DCM/MeOH 9:1).

Sources & evidence

ORD record
ord-2d2447650f6042cbaae77625337a2d56
Source dataset
uspto-grants-2010_07
Patent number
US07754727B2

Reaction notes

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