1-Methyl-3-aminopyrazole → HCID 23092992, compound

HRID 2355012Notes

Reaction equation

HRID 2355012 reaction equation
CO[C:3](=[O:34])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[N:13][C:14]([S:17]([CH2:20][CH3:21])(=[O:19])=[O:18])=[CH:15][CH:16]=2)[CH:7]=[C:6]([O:22][C@@H:23]([CH3:33])[CH2:24][O:25][Si](C(C)(C)C)(C)C)[CH:5]=1.[NH2:35][C:36]1[CH:40]=[CH:39][N:38]([CH3:41])[N:37]=1>>[CH2:20]([S:17]([C:14]1[N:13]=[CH:12][C:11]([O:10][C:8]2[CH:9]=[C:4]([CH:5]=[C:6]([O:22][CH:23]([CH3:33])[CH2:24][OH:25])[CH:7]=2)[C:3]([NH:35][C:36]2[CH:40]=[CH:39][N:38]([CH3:41])[N:37]=2)=[O:34])=[CH:16][CH:15]=1)(=[O:18])=[O:19])[CH3:21]

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 68704759HCID 68704759, compound

Product 1

HCID 23092992HCID 23092992, compound

Procedure

The compound of Production Example 117 was obtained as a colorless amorphous substance using the obtained 3-((1S)-2-(t-butyldimethylsiloxy)-1-methyl-ethoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzoic acid methyl ester and 3-amino-1-methylpyrazole, by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 117 was obtained as a colorless amorphous substance

Sources & evidence

ORD record
ord-a3f0a42f43c34427ad8fb7439ebb95d5
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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