1-Methyl-3-aminopyrazole → HCID 68708416, compound

HRID 2355013Notes

Reaction equation

HRID 2355013 reaction equation
O(C[C@H:10]([OH:12])C)[Si](C(C)(C)C)(C)C.N[C:14]1C=CN(C)N=1.[CH3:20][O:21][C:22](=[O:42])[C:23]1[CH:28]=[C:27]([OH:29])[CH:26]=[C:25]([O:30][C:31]2[CH:36]=[CH:35][C:34]([C:37](=[O:41])[N:38]([CH3:40])[CH3:39])=[CH:33][CH:32]=2)[CH:24]=1>>[CH3:20][O:21][C:22](=[O:42])[C:23]1[CH:28]=[C:27]([O:29][CH2:14][O:12][CH3:10])[CH:26]=[C:25]([O:30][C:31]2[CH:32]=[CH:33][C:34]([C:37](=[O:41])[N:38]([CH3:39])[CH3:40])=[CH:35][CH:36]=2)[CH:24]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 68713320HCID 68713320, compound

Product 1

HCID 68708416HCID 68708416, compound

Procedure

The compound of Production Example 122 was obtained as a colorless amorphous substance by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method, using (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane, 3-amino-1-methyl-1H-pyrazole and 3-(4-dimethylcarbamoyl-phenoxy)-5-hydroxy-benzoic acid methyl ester obtained by deprotection of the methoxymethyl group of 3-(4-dimethylcarbamoyl-phenoxy)-5-methoxymethoxy-benzoic acid methyl ester obtained by converting the formyl group of 3-(4-formyl-phenoxy)-5-methoxymethoxy-benzoic acid methyl ester obtained in the same manner as Production Example 1, using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester and p-formylphenylboric acid, to carboxyl, followed by condensation with dimethylamine.

Workup

  1. customThe compound of Production Example 122 was obtained as a colorless amorphous substance by the same method as in Production Example 2

Sources & evidence

ORD record
ord-b0313709753248e99ca9016d1c483ee2
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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