1-Methyl-3-aminopyrazole → HCID 68711640, compound

HRID 2355014Notes

Reaction equation

HRID 2355014 reaction equation
O(C[C@H:10]([OH:12])C)[Si](C(C)(C)C)(C)C.N[C:14]1C=CN(C)N=1.[CH3:20][O:21][C:22](=[O:40])[C:23]1[CH:28]=[C:27]([OH:29])[CH:26]=[C:25]([O:30][C:31]2[CH:36]=[CH:35][C:34]([C:37](=[O:39])[CH3:38])=[CH:33][CH:32]=2)[CH:24]=1>>[CH3:20][O:21][C:22](=[O:40])[C:23]1[CH:28]=[C:27]([O:29][CH2:14][O:12][CH3:10])[CH:26]=[C:25]([O:30][C:31]2[CH:36]=[CH:35][C:34]([C:37](=[O:39])[CH3:38])=[CH:33][CH:32]=2)[CH:24]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 68708442HCID 68708442, compound

Product 1

HCID 68711640HCID 68711640, compound

Procedure

The compound of Production Example 123 was obtained as a colorless amorphous substance by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method, using (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane, 3-amino-1-methyl-1H-pyrazole and 3-(4-acetyl-phenoxy)-5-hydroxy-benzoic acid methyl ester obtained by deprotection of the methoxymethyl group of 3-(4-acetyl-phenoxy)-5-methoxymethoxy-benzoic acid methyl ester obtained by reaction of the formyl group of 3-(4-formyl-phenoxy)-5-methoxymethoxy-benzoic acid methyl ester obtained by the same method as in Production Example 122 with methylmagnesium bromide, followed by oxidation.

Workup

  1. customThe compound of Production Example 123 was obtained as a colorless amorphous substance by the same method as in Production Example 2

Sources & evidence

ORD record
ord-c0d6234075374029aba43787ac6a5b1e
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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