5-Amino-3-methyl-1,2,4-thiadiazole → HCID 68710230, compound

HRID 2355017Notes

Reaction equation

HRID 2355017 reaction equation
O(C[C@H:10]([OH:12])C)[Si](C(C)(C)C)(C)C.N[C:14]1SN=C(C)N=1.[CH3:20][O:21][C:22](=[O:43])[C:23]1[CH:28]=[C:27]([OH:29])[CH:26]=[C:25]([O:30][C:31]2[CH:36]=[CH:35][C:34]([CH2:37][NH:38][C:39]([O:41][CH3:42])=[O:40])=[CH:33][CH:32]=2)[CH:24]=1>>[CH3:20][O:21][C:22](=[O:43])[C:23]1[CH:28]=[C:27]([O:29][CH2:14][O:12][CH3:10])[CH:26]=[C:25]([O:30][C:31]2[CH:32]=[CH:33][C:34]([CH2:37][NH:38][C:39]([O:41][CH3:42])=[O:40])=[CH:35][CH:36]=2)[CH:24]=1

Participants

4

Reactant 3

HCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 68709177HCID 68709177, compound

Product 1

HCID 68710230HCID 68710230, compound

Procedure

The compound of Production Example 127 was obtained as a colorless amorphous substance by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method, using (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane, 5-amino-3-methyl-[1,2,4]-thiadiazole and 3-(4-methoxycarbonylaminomethylphenoxy)-5-hydroxy-benzoic acid methyl ester obtained by deprotection of the methoxymethyl group of 3-(4-methoxycarbonylaminomethylphenoxy)-5-methoxymethoxy-benzoic acid methyl ester obtained by the same method as in Production Example 59, using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester instead of 5-hydroxy-3-isopropoxybenzoic acid methyl ester.

Workup

  1. customThe compound of Production Example 127 was obtained as a colorless amorphous substance by the same method as in Production Example 2

Sources & evidence

ORD record
ord-90063a44f4954867a65da67e4515aaf7
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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