1-Methyl-3-aminopyrazole → HCID 23092998, compound

HRID 2355018Notes

Reaction equation

HRID 2355018 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[O:27]([CH2:35][C@@H:36]([OH:39])[CH2:37][CH3:38])[Si](C(C)(C)C)(C)C.[NH2:40][C:41]1[CH:45]=[CH:44][N:43]([CH3:46])[N:42]=1>>[OH:27][CH2:35][CH:36]([O:39][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:22]=[N:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:40][C:41]1[CH:45]=[CH:44][N:43]([CH3:46])[N:42]=1)=[O:15])[CH2:37][CH3:38]

Participants

5

Reactant 4

HCID 1372541-Methyl-3-aminopyrazoleHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoateHCID 86606837HCID 86606837, compound

Product 1

HCID 23092998HCID 23092998, compound

Procedure

The compound of Production Example 128 was obtained as a colorless amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, (2S)-1-(tert-butyldimethylsiloxy)-2-hydroxybutane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 128 was obtained as a colorless amorphous substance

Sources & evidence

ORD record
ord-cce2adbaa22745859db6d5de07353a3b
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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