1-Methyl-3-aminopyrazole → HCID 23092993, compound

HRID 2355019Notes

Reaction equation

HRID 2355019 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[CH3:27][O:28][CH2:29][C@@H:30]([OH:33])[CH2:31][CH3:32].[NH2:34][C:35]1[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=1>>[CH3:26][S:23]([C:20]1[N:21]=[CH:22][C:17]([O:10][C:8]2[CH:9]=[C:4]([CH:5]=[C:6]([O:33][CH:30]([CH2:29][O:28][CH3:27])[CH2:31][CH3:32])[CH:7]=2)[C:3]([NH:34][C:35]2[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:25])=[O:24]

Participants

5

Reactant 4

HCID 1372541-Methyl-3-aminopyrazoleHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoateHCID 59990750HCID 59990750, compound

Product 1

HCID 23092993HCID 23092993, compound

Procedure

The compound of Production Example 129 was obtained as a colorless amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, (2S)-1-methoxy-2-hydroxybutane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 129 was obtained as a colorless amorphous substance

Sources & evidence

ORD record
ord-47a77ae4e7124f1582b199f62ca70b8e
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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