1-Methyl-3-aminopyrazole → HCID 23093040, compound

HRID 2355028Notes

Reaction equation

HRID 2355028 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8](O)[CH:7]=[C:6]([O:11][CH2:12]OC)[CH:5]=1.BrC1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.O[C@H:28]1[CH2:32][CH2:31][O:30][CH2:29]1.[NH2:33][C:34]1[CH:38]=[CH:37][N:36]([CH3:39])[N:35]=1>>[CH3:26][S:23]([C:20]1[N:21]=[CH:22][C:12]([O:11][C:6]2[CH:5]=[C:4]([CH:9]=[C:8]([CH:28]3[CH2:32][CH2:31][O:30][CH2:29]3)[CH:7]=2)[C:3]([NH:33][C:34]2[CH:38]=[CH:37][N:36]([CH3:39])[N:35]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:24])=[O:25]

Participants

5

Reactant 4

HCID 1372541-Methyl-3-aminopyrazoleHCID 2733227(S)-(+)-3-HydroxytetrahydrofuranHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093040HCID 23093040, compound

Procedure

The compound of Production Example 141 was obtained as a colorless oil using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, (S)-(+)-3-hydroxytetrahydrofuran and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 141 was obtained as a colorless oil

Sources & evidence

ORD record
ord-7ba0fdb9995740199158bce72533854d
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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