1-ethyl-1H-pyrazol-3-amine → HCID 23093029, compound

HRID 2355029Notes

Reaction equation

HRID 2355029 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[O:27]([CH2:35][C@H:36]([OH:38])[CH3:37])[Si](C(C)(C)C)(C)C.[NH2:39][C:40]1[CH:44]=[CH:43][N:42]([CH2:45][CH3:46])[N:41]=1>>[CH2:45]([N:42]1[CH:43]=[CH:44][C:40]([NH:39][C:3](=[O:15])[C:4]2[CH:5]=[C:6]([O:38][CH:36]([CH3:37])[CH2:35][OH:27])[CH:7]=[C:8]([O:10][C:17]3[CH:22]=[N:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=3)[CH:9]=2)=[N:41]1)[CH3:46]

Participants

5

Reactant 4

HCID 121981091-ethyl-1H-pyrazol-3-amineHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093029HCID 23093029, compound

Procedure

The compound of Production Example 142 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, (2R)-1-(tert-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-ethyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 142 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-3424a3a1ca134035a45cea23726d41e8
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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