1,3-Difluoro-2-propanol → HCID 178504808, compound

HRID 2355030Notes

Reaction equation

HRID 2355030 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[F:27][CH2:28][CH:29]([OH:32])[CH2:30][F:31].[NH2:33][C:34]1[CH:38]=[CH:37][NH:36][N:35]=1>>[F:27][CH2:28][CH:29]([CH2:30][F:31])[O:32][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:22]=[N:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:33][C:34]1[CH:38]=[CH:37][NH:36][N:35]=1)=[O:15]

Participants

5

Reactant 4

HCID 679851,3-Difluoro-2-propanolHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoateHCID 178418806HCID 178418806, compound

Product 1

HCID 178504808HCID 178504808, compound

Procedure

The compound of Production Example 143 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, 1,3-difluoro-2-propanol and 3-amino-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 143 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-a14df31a460e4b93ad818eb453048b00
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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