HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-aminopyrazole → 5-(2-hydroxy-1-methyl-ethoxy)-3-(6-isopropylsulfonylpyridin-3-yloxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | (2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-ol | HCID 13175135 | — |
| Reactant | HCID 13433423 | HCID 13433423 | — |
| Reactant | Methyl 3-hydroxy-5-(methoxymethoxy)benzoate | HCID 23136427 | — |
| Product | 5-(2-hydroxy-1-methyl-ethoxy)-3-(6-isopropylsulfonylpyridin-3-yloxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide | HCID 23093063 | — |
Reaction Steps
The compound of Production Example 159 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-isopropylsulfonylpyridine, (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754743B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-8cd0fc3113064534a6bdfd331069bfb5 |
| Source note | uspto-grants-2010_07 |