HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-aminopyrazole → 3-(3-chloro-4-methanesulfonylphenoxy)-5-(2-hydroxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Reactant | (2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-ol | HCID 13175135 | — |
| Reactant | 4-Bromo-2-chloro-1-methanesulfonylbenzene | HCID 23093061 | — |
| Reactant | Methyl 3-hydroxy-5-(methoxymethoxy)benzoate | HCID 23136427 | — |
| Product | 3-(3-chloro-4-methanesulfonylphenoxy)-5-(2-hydroxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide | HCID 23092996 | — |
Reaction Steps
The compound of Production Example 160 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 4-bromo-2-chloro-methanesulfonylbenzene, (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 42, a corresponding method, or a combination thereof with an ordinary method.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754743B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-cd75dd1d56db4751ad5a701cea8a8f37 |
| Source note | uspto-grants-2010_07 |