3-Iodopyridine → HCID 23093073, compound

HRID 2355040Notes

Reaction equation

HRID 2355040 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.I[C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1.[O:23]([CH2:31][C@H:32]([OH:34])[CH3:33])[Si](C(C)(C)C)(C)C.[NH2:35][C:36]1[CH:40]=[CH:39][N:38]([CH3:41])[N:37]=1>>[OH:23][CH2:31][CH:32]([CH3:33])[O:34][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:35][C:36]1[CH:40]=[CH:39][N:38]([CH3:41])[N:37]=1)=[O:15]

Participants

5

Reactant 4

HCID 707143-IodopyridineHCID 1372541-Methyl-3-aminopyrazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093073HCID 23093073, compound

Procedure

The compound of Production Example 161 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 3-iodopyridine, (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 161 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-a5e0744c2d754f10b584970360555554
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

Loading…