1,3-Difluoro-2-propanol → HCID 23092962, compound

HRID 2355044Notes

Reaction equation

HRID 2355044 reaction equation
CO[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([O:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[C:14]([F:22])[CH:13]=2)[CH:5]=1.[F:24][CH2:25][CH:26](O)[CH2:27][F:28].[NH2:30][C:31]1[CH:35]=[CH:34][N:33]([CH3:36])[N:32]=1>>[F:24][CH2:25][CH:26]([CH2:27][F:28])[O:10][C:8]1[CH:7]=[C:6]([O:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:19])=[O:20])=[C:14]([F:22])[CH:13]=2)[CH:5]=[C:4]([CH:9]=1)[C:3]([NH:30][C:31]1[CH:35]=[CH:34][N:33]([CH3:36])[N:32]=1)=[O:23]

Participants

4

Reactant 3

HCID 679851,3-Difluoro-2-propanolHCID 1372541-Methyl-3-aminopyrazoleHCID 68706979HCID 68706979, compound

Product 1

HCID 23092962HCID 23092962, compound

Procedure

The compound of Production Example 166 was obtained as a colorless amorphous substance using 3-(3-fluoro-4-methanesulfonylphenoxy)-5-hydroxy-benzoic acid methyl ester, 1,3-difluoro-2-propanol and 3-amino-1-methyl-1H-pyrazole obtained in the same manner as Production Example 42, by the same method as in Production Example 2, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 166 was obtained as a colorless amorphous substance
  2. customobtained in the same manner as Production Example 42, by the same method as in Production Example 2

Sources & evidence

ORD record
ord-15f7e6f2997143919b66f5b270162be4
Source dataset
uspto-grants-2010_07
Patent number
US07754743B2

Reaction notes

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