Cesium carbonate → HCID 59383121, compound

Participants

Reaction Conditions

Reaction Steps

Dry, degassed DMF (90 ml) was added to 4-chlorophenylcyclopropyl ketone (5.0 g, 27.6 mmol), N-(4-Methyl-thiazol-2-yl)-acetamide (3.6 g, 23.1 mmol), Bis(tri-t-butylphosphine) palladium (0) (1.18 g, 2.31 mmol) and caesium carbonate (15.03 g, 46.1 mmol), and the reaction mixture heated to 150° C. for 4 hours. The reaction mixture was filtered through celite and the filtrate reduced in vacuo. The material was purified by column chromatography using as eluant 2:1 to 1:2 Iso-hexane:EtOAc gradient. (M+H) 259.0.

Provenance & Evidence