Sodium Hydroxide → [4-(2-Amino-4-methyl-thiazol-5-yl)-phenyl]-cyclopropyl-methanone

Participants

Reaction Conditions

Reaction Steps

Ethanol (34 ml) and 6M NaOH (18.6 ml, 113.2 mmol) were added to N-[5-(4-Cyclopropanecarbonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (3.4 g, 11.32 mmol). The reaction mixture was heated to 85° C. for 5.5 hours, after which further NaOH (3.72 ml, 22.64 mmol) was added and heating continues for 1.5 hours. The resulting precipitate was isolated by vacuum filtration. (M+H) 301.26.

Provenance & Evidence