2-Bromophenol → 960491-89-8

HRID 2355054Notes

Reaction equation

HRID 2355054 reaction equation
[ClH:1].FC(F)(F)[C:4]1[CH:15]=[CH:14][CH:13]=[CH:12][C:5]=1[O:6][C@H:7]1[CH2:11][CH2:10][NH:9][CH2:8]1.O[C@@H]1CCN(C(OC(C)(C)C)=O)C1.[Br:31]C1C=CC=CC=1O>>[ClH:1].[Br:31][C:4]1[CH:15]=[CH:14][CH:13]=[CH:12][C:5]=1[O:6][C@H:7]1[CH2:11][CH2:10][NH:9][CH2:8]1

Participants

4

Reactant 3

HCID 72442-BromophenolHCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylateHCID 46942099HCID 46942099, compound

Product 1

HCID 68452458960491-89-8

Procedure

The title compound was prepared in the same manner as described for (3S)-3-[2-(trifluoromethyl)phenoxy]pyrrolidine hydrochloride from tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate and 2-bromophenol. 1H NMR (300 MHz, DMSO-d6): δ 7.60 (m, 1H), 7.35 (m, 1H), 7.18 (m, 1H), 6.94 (m, 1H), 5.18 (s, 1H), 3.53 (d, 1H), 3.32 (m, 3H), 2.14 (m, 2H).

Sources & evidence

ORD record
ord-f7841768140446a6980ec0d74caa3842
Source dataset
uspto-grants-2010_07
Patent number
US07754745B2

Reaction notes

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